Arsenal will be without left-back Kieran Tierney against Manchester City after the international break, with the Scot required to self-isolate for 14 days after coming in to contact with Southampton’s Stuart Armstrong.
The Scotland national team confirmed on Wednesday that Tierney and Celtic’s Ryan Christie had been in close contact with Armstrong, who has contracted COVID-19.
One unnamed physiotherapist and one masseur will also be required to go into a two-week period of isolation.
Armstrong was the only player in the Scotland squad to test positive despite having initially tested negative after reporting for international duty on Monday.
His diagnosis emerged on Wednesday after a supplementary UEFA test came back positive, with the midfielder now self-isolating for 10 days from Tuesday.
The trio will miss their country’s Euro 2020 play-off semi-final against Israel as well as Nations League matches against Slovakia and Czech Republic.
Scotland manager Steve Clarke said: “While this is obviously disappointing news the most important thing is the health and safety of the individuals involved and the wider group.
“We have informed the respective clubs from whom we have borrowed the players and backroom staff and we now have to prepare for a huge match ahead tomorrow.”